AdrenodoxinReductase，AdR,Ferredoxin Reductase（ADXR)

(Adrenal) cortical ferredoxin reductase (AdR, NADPH: Adrenal ferredoxin oxidoreductase, EC 1.18.1.2) is a monomeric flavoenzyme, containing FAD prosthetic group, with a molecular weight of about 51kDa, and is involved in almost all enzymes in the human body Biosynthesis of nearly all steroid hormones.

 

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The mammalian mitochondrial P450 monooxygenase system consists of NADPH-dependent cortical ferredoxin reductase (ADR), cortical ferredoxin (ADX), and mitochondrial P450. In this electron transport chain, electrons are transferred from NADPH to mitochondrial P450 via ADR and ADX.

 

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In the process of cytochrome P450scc catalyzing the hydroxylation of C-22 and C-20 in the cholesterol structure, and then cleaving the carbon chain between them to form pregnenolone, 2 pairs of electrons are passed by NADPH in each catalytic step. Cortical ferredoxin and its reductase are transported to cytochrome P450scc.

 

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Our company's (adrenal gland) cortical ferredoxin reductase is a genetically recombinant product and does not contain animal-derived viruses. The product has high purity and good activity.

 

Source: Gene recombinant expression

 

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Molecular weight: 51 kDa (SDS-PAGE detection)

 

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Purity: ≥90% (SDS-PAGE detection)

 

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Storage conditions: freeze-dried powder stored at 4℃ or long-term storage at -20℃

 

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Transportation conditions: low temperature ice pack

 

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Safety Tips: Not for human experimentation

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