Tim-3(T cell immunoglobulin and mucin domain-3)

T cell immunoglobulin and mucin domain-3 (Tim-3), also known as HAVCR2, is a member of the TIM family of immune regulatory molecules. It is a type I transmembrane glycoprotein with a molecular weight of 60kD. . Mature human Tim-3 consists of an extracellular domain of 181aa, a transmembrane domain of 21aa, and a cytoplasmic domain of 78aa. Tim-3 is an important member of the T cell immunoglobulin molecule family. It is a key molecule expressed by activated Th1 cells that regulates CD4+CD25+ regulatory T (TR) cells. Th1 cells express full-length membrane Tim3 (flTim3) and soluble Tim3 (sTim3) through selective splicing of mRNA. Tim-3 is mainly expressed in differentiated mature Th1 cells, and after binding to its ligand galectin-9, it can downregulate the Th1 type cellular immune response.

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Tim3-his and Tim3-Fc expressed in mammalian cells by our company have high purity and good activity.

Tim3(His tag) Tim3(Fc tag)

Cat# Abt-P-4022 a Cat#Abt-P-4022 b

Expression host: HEK293 Expression host: HEK293

Molecular weight: 28-52 kDa Molecular weight: 54-80 kDa

Concentration: 1-2mg/mL Concentration: 1-2mg/mL

Purity: >90% Purity: >90%

Storage environment: 1×PBS (pH7.4) Storage environment: 1×PBS (pH7.4)

Storage conditions: short-term storage at 4℃, long-term storage at -20℃. Avoid repeated freezing and thawing

Safety Tips: Not for human experimentation