Cytotoxic T lymphocyte-associated antigen-4（CTLA-4）

Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4), also known as CD152, is a leukocyte differentiation antigen and a transmembrane receptor on T cells. CTLA-4 consists of a 35aa signal peptide, a 126aa extracellular region, a 21aa transmembrane region and a 41aa cytoplasmic region. CTLA-4 and CD28 share the B7 molecule ligand, and the combination of CTLA-4 and B7 molecules induces T cell anergy and participates in the negative regulation of immune responses. Genetically recombinant CTLA-4 Ig can effectively and specifically inhibit cellular and humoral immune responses in vivo and in vitro. It has a significant therapeutic effect on transplant rejection and various autoimmune diseases. It has extremely low toxic and side effects and is currently considered to be the most effective. Promising new immunosuppressive drugs.

​

The CTLA4-his and CTLA-Fc expressed in mammalian cells of our company have high purity and good activity.

​

CTLA4(His tag) CTLA4(Fc tag)

Cat# Abt-P-4011 a Cat#Abt-P-4011 b

Expression host: HEK293 Expression host: HEK293

Molecular weight: 22-27 kDa Molecular weight: 50-55 kDa

Concentration: 1-2mg/mL Concentration: 1-2mg/mL

Purity: >90% Purity: >90%

Storage environment: 1×PBS (pH7.4) Storage environment: 1×PBS (pH7.4)

Storage conditions: short-term storage at 4℃, long-term storage at -20℃. Avoid repeated freezing and thawing

Safety Tips: Not for human experimentation