Receptor induced by lymphocyte activation（ILA）4-1BB his/Fc tag

4-1BB is called receptor induced by lymphocyte activation (ILA), also known as CD137, and also known as tumor necrosis factor receptor superfamily member 9, TNFRSF9. The costimulatory molecule 4-1 BB and its ligands are members of the tumor necrosis factor receptor superfamily. 4-1BB is a type I transmembrane protein. The mature 4-1BB protein contains 256 amino acids and a relative molecular mass of 30kD. It is mainly composed of a 163aa extracellular region, a 27aa transmembrane region and a 42aa cytoplasmic region. The ligand of 4-1BB, 4-1BBL, is a type II transmembrane glycoprotein that is mainly expressed in professional antigen-presenting cells, such as B cells, macrophages and dendritic cells (dendritic cells, DC). The human 4-1BBL gene encodes a protein consisting of 254 amino acids, which has two forms: membrane-bound and soluble forms, both of which have biological activity.

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The interaction between 4-1BB and its ligand 4-1 BBL can provide a second signal independent of CD28 signal for T cell activation, induce T cell proliferation, differentiation and cytokine production, and participate in autoimmune diseases and tumors. , viral infection, transplant rejection and inflammation of the immune regulatory process, its regulatory function and regulatory mechanism have now become a hot spot in immunological research.

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The 4-1BB-his and 4-1BB-Fc expressed in mammalian cells by our company have high purity and good activity.

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4-1BB(His tag) 4-1BB(Fc tag)

Cat# Abt-P-4001 a Cat# Abt-P-4001 b

Expression host: HEK293 Expression host: HEK293

Molecular weight: 33-40 kDa Molecular weight: 52-65 kDa

Concentration: 1-2mg/mL Concentration: 1-2mg/mL

Purity: >90% Purity: >90%

Storage environment: 1×PBS (pH7.4) Storage environment: 1×PBS (pH7.4)

Storage conditions: short-term storage at 4℃, long-term storage at -20℃. Avoid repeated freezing and thawing

Safety Tips: Not for human experimentation