NT-proBNP Antibody（ NT-proBNP Ab）

The forms of brain natriuretic peptide in myocardial cells include brain natriuretic peptide precursor (also known as protobrain natriuretic peptide, ProBNP), brain natriuretic peptide (BNP), and N-terminal probrain natriuretic peptide (also known as amino-terminal probrain natriuretic peptide, NT). -ProBNP) three types.

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BNP is a polypeptide composed of 32 amino acids and a cyclic structure composed of 17 amino acids. It is a short peptide hormone secreted by the heart. The 134-amino-acid Pre-pro-BNP synthesized in cardiomyocytes is degraded after entering the blood circulation to produce a 108-amino-acid BNP precursor (proBNP). ProBNP forms a biologically active BNP and a Inactive 76 amino acid fragment NT-proBNP.

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BNP is a biologically active protein with a half-life of 20 minutes, and its in vitro stability time is only 1 hour, and its level is easily affected by the selected drug. For example, when patients receive recombinant human brain BNP (rh-BNP) treatment, Resulting in increased BNP levels in the blood. For elevated BNP levels, it is difficult for clinicians to determine whether it is caused by drug treatment or cardiac dysfunction.

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As an inactive NT-proBNP, it has a half-life of 60-120 minutes and an in vitro stability time of up to 24 hours. It has higher sensitivity and is not affected by rh-BNP, making it easier for clinicians to accurately detect early and mild heart failure.

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Our company's NT-proBNP antibody has a high potency and can be directly used in the development or production of NT-proBNP detection reagents.

Source: Rabbit, polyclonal antibody

Purification method: Protein A affinity purification

Potency: 1: 100,000-1 million

Buffer composition: PBS, 0.1% preservative

Storage conditions: It can be stored for one year at 4℃ and two years at -20℃ (it is recommended to store in separate packages and try to avoid repeated freezing and thawing)

Safety Tips: Not for human experimentation