NT-proBNP

The forms of brain natriuretic peptide in myocardial cells include brain natriuretic peptide precursor (also known as protobrain natriuretic peptide, ProBNP), brain natriuretic peptide (BNP), and N-terminal probrain natriuretic peptide (also known as amino-terminal probrain natriuretic peptide, NT). -ProBNP) three types.

BNP is a polypeptide composed of 32 amino acids and a cyclic structure composed of 17 amino acids. It is a short peptide hormone secreted by the heart. The 134-amino-acid Pre-pro-BNP synthesized in cardiomyocytes is degraded after entering the blood circulation to produce a 108-amino-acid BNP precursor (proBNP). ProBNP forms a biologically active BNP and a Inactive 76 amino acid fragment NT-proBNP.

BNP is a biologically active protein with a half-life of 20 minutes, and its in vitro stability time is only 1 hour, and its level is easily affected by the selected drug. For example, when patients receive recombinant human brain BNP (rh-BNP) treatment, Resulting in increased BNP levels in the blood. For elevated BNP levels, it is difficult for clinicians to determine whether it is caused by drug treatment or cardiac dysfunction.

As an inactive NT-proBNP, it has a half-life of 60-120 minutes and an in vitro stability time of up to 24 hours. It has higher sensitivity and is not affected by rh-BNP, making it easier for clinicians to accurately detect early and mild heart failure.

​

Human NT-proBNP Human NT-proBNP

Cat# Abt-P-2002a Cat#Abt-P-2002b

Expression host: E.coli Expression host: HEK293

Molecular weight: 13kDa Molecular weight: 17-27 kDa

Concentration: 1-2mg/mL Concentration: 1-2mg/mL

Purity: >90% Purity: >90%

Storage environment: 1×PBS (pH7.4) Storage environment: 1×PBS (pH: 7.4)

Storage conditions: short-term storage at 4℃, long-term storage at -20℃. Avoid repeated freezing and thawing.

Safety Tips: Do not use for human experiments