Heart Fatty Acid-Bindingprotein（HFABP）

Heart-shaped fatty acid binding protein (HFABP, also known as FABP3) consists of 132 amino acids and has a molecular weight of 15 kDa. It is one of the most abundant proteins in the heart. hFABP binds two fatty acid molecules and participates in the transport of fatty acyl-CoA, active in the oxidation process, thereby generating energy in the mitochondria.

Heart-type fatty acid binding protein (HFABP) is a novel small cytoplasmic protein abundant in the heart. It is highly cardiac specific (that is, expressed primarily in cardiac tissue), but is also expressed at low concentrations in tissues other than the heart. After myocardial ischemic injury occurs, HFABP can be found in the blood as early as 1-3 hours after the onset of chest pain, reaching a peak value at 6-8 hours and plasma levels return to normal within 24-30 hours. Therefore HFABP is regarded as a useful biomarker for early diagnosis of myocardial injury.

Elevated levels of free plasma myoglobin are a widely accepted marker of early myocardial injury and have been shown to exclude acute myocardial infarction within 3-6 hours of symptom onset compared to elevated levels of CK-MB and cTnT. (AMI). But HFABP is more heart-specific and is considered a more accurate diagnostic test because of its biological properties.

Furthermore, human HFABP can be used as a good biomarker for myocardial infarction detection with high sensitivity and detection rate.

Source: Gene recombinant expression

Molecular weight: 15 kDa (SDS-PAGE detection)

Purity: ≥90% (SDS-PAGE detection)

Storage conditions: freeze-dried powder can be stored at 4℃ for one year and -20℃ for two years (it is recommended to store in separate packages to avoid repeated freezing and thawing)

Transport conditions: low temperature ice pack

Do not use for human experiments