Fibroblast Activation Protein（FAP）

SKU: HT-628159

Lead Time

5-15 days

Shipping

Sea freight, Air freight, Express

Payment

T/T, L/C

Sample

Available

Product details

Product overview

(Fibroblast activation protein alpha)

“Fibroblast activation protein alpha” , also known as seprase or 170 kDa melanoma membrane-bound gelatinase , is a protein that in humans is encoded by the FAP gene(2q23). It is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis.

FAP, also known as seprase, belongs to the clan SC proteases and is a member of the S9B prolyl oligopeptidase subfamily. Other members of the S9B subfamily are DPPIV, DPP8 and DPP9. FAP is most closely related to DPPIV and they share about 50% of their amino acids.

FAP is catalytically active as a 170kD dimer and has dipeptidase and gelatinase activity. Its gelatinase activity requires a glycine in P2 position.

The FAP provided by our company is gene recombinant protein of mammalian cell, with a high purity, good immunogenicity and high biological activity.

Product details：

Cat # ：	Abt-P-2011
Form:	liquid
Constituents:	Recombinant human FAP was dissolved in PBS (pH7.4).
Concentration：	2mg/ml
Shipment：	ice bag
Source：	A DNA sequence encoding the human FAP isoform 1 (NM_004460.3) extracellular domain (Leu26-Asp760) fused with a polyhistidie-tag was expressed by HEK293 cells.
Molecular weight:	Recombinant human FAP migrates as approximately 90 kDa band in SDS-PAGE under reducing conditions.
Purity：	95%（determined by SDS-PAGE）
Storage：	4 °C for frequent usage, -20 °C for long-term storage. Avoid repeated freeze-thaw cycles.
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