Human Epididymis Protein 4（HE4）Fc tag

Ovarian cancer is malignant tumor, which is commonly occurred in ovarian tissue. Its incidence is the third of the three major gynecological malignant tumors. For its early symptom is not obvious and not easy to find, the 5-year survival rate of patients decreases from 70-90% to 20% as the time goes on, so early diagnosis is important for the cure rate of ovarian cancer. HE4 are surface antigen of women ovarian tumor cell. Although CA125 is widely used in the clinical diagnosis of ovarian cancer, studies have shown that HE4 has more advantages in the early diagnosis of ovarian cancer than CA125, especially for patients at the start of ovarian cancer. HE4 is the best tumor markers currently in ovarian cancer diagnosis.

HE4 is found in epididymis epithelium. HE4 is the product of selective cutting of WFDC2 gene and has a highly conservative WAP (Whey Acidic Proteins) domain structure, which has four disulfide bond core region that formed by eight cysteine.    

Our HE4 is gene recombinant protein of mammalian cells with high purity, good immunogenicity and biological activity. It is a fusion protein with human Fc fragment.  Antibody to this antigen protein can be used as the core material of ovarian cancer early diagnosis kit, and the protein itself can also be used as calibration items.

Product details：

Not for use on humans.