Inducible Costimulator（ICOS）

The inducible costimulator ICOS (Inducible costimulator), also known as AILIM (activiation-inducible lymphocyte immunomediatory molecule), or CRP-1 (CD28-related protein-1), is a member of the CD28 family. ICOS is a homodimer composed of two subunits. It is a type I transmembrane protein and belongs to the immunoglobulin superfamily. ICOS consists of 199aa, including 20aa signal peptide, 121aa extracellular region, 23aa transmembrane region and 35aa cytoplasmic region. Its cytoplasmic region contains a YMFM motif, which can bind to PI3K kinase; the extracellular region contains a V-like Ig functional region, in which the FDPPF motif is a structure that binds to the corresponding ligand ICOSL. The gene product of COSL is a transmembrane glycoprotein composed of 309 amino acids, approximately 63 to 72 kD. The extracellular region is similar to other molecules of the B7 family, including IgV and IgC regions. The intracellular segment of this molecule is adapted to different physiological environments and The state of the cell itself is spliced to form different isoforms. The four cysteines and the tyrosine at position 80 in the IgV region are conserved sites. They are not only iconic sites of the B7 family, but are also very important for the formation of immunoglobulin-like structures.

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The costimulatory signal mediated by the combination of ICOS and its ligand ICOSL can regulate the activation, proliferation and secretion of cytokines of T cells. In recent years, studies have confirmed that the ICOS/ICOSL signaling pathway is related to inflammatory responses, autoimmune diseases, tumors, and transplant rejection.

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ICOS-his and ICOS-Fc expressed in mammalian cells of our company have high purity and good activity.

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Expression host: HEK293

​Molecular weight: 45-52kDa

Concentration: 1-2mg/mL

Purity: >90%

Storage environment: 1×PBS (pH7.4)

Storage conditions: short-term storage at 4℃, long-term storage at -20℃. Avoid repeated freezing and thawing

Safety Tips: Not for human experimentation