Her2 ErbB2

SKU: HT-628204

Lead Time

5-15 days

Shipping

Sea freight, Air freight, Express

Payment

T/T, L/C

Sample

Available

Product details

Product overview

(Human epidermal growth factor receptor 2)

Human epidermal growth factor receptor 2 (HER2), also known as ErbB2, is a type I membrane glycoprotein, and belongs to the epidermal growth factor (EGF) receptor family. It has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase.

It is a protein giving higher aggressiveness in breast cancers. Approximately 30% of breast cancers have an amplification of the HER2 gene or overexpression of its protein product. Overexpression of this receptor in breast cancer is associated with increased disease recurrence and worse prognosis. HER2 appears to play roles in development, cancer, communication at the neuromuscular junction andregulation of cell growth and differentiation.

The HER2 provided by our company is gene recombinant protein of mammalian cell, with a high purity, good immunogenicity and high biological activity.

Product details：

Cat # ：	Abt-P-4014
Form:	liquid
Constituents:	Recombinant human Her2 was dissolved in 1×PBS (pH7.4).
Concentration：	1mg/ml
Shipment：	ice bag
Source：	A DNA sequence encoding the human ErbB2 (NM_004448.3) extracellular domain (Thr23-Thr652) fused with a polyhistidine tag was expressed by HEK293 cells.
Molecular weight:	Recombinant human Her2/ErbB2 migrates as approximately 100-110 kDa band in SDS-PAGE under reducing conditions.
Purity：	95%（determined by SDS-PAGE）
Storage：	4°C for frequent usage, -20°C for long-term storage. Avoid repeated freeze-thaw cycles.
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