EGFR（ErbB1）

EGFR is a member of the epidermal growth factor receptor family. EGFR is a type I transmembrane glycoprotein that can bind a series of family ligands, including EGF (epidermal growth factor), amphiregulin (amphiregulin), and TGF-α (transforming growth factor). factor-alpha subunit), betacellulin (cytoregulin), etc. EGFR plays an important role in regulating cell proliferation, survival, differentiation and other pathways. EGFR binds ligands to induce homologous or heterodimerization, which is followed by tyrosine autophosphorylation and activation of various downstream pathways: mitogen-activated protein (MAPK), phosphatidylinositol kinase -3(PI3K)-Akt(PI3K/PKB) and signal transduction and transcription factor 3 (STAT). In addition, EGFR signaling also affects carcinogenesis and disease progression, so EGFR is currently used as a target for cancer treatment.

​

The EGFR produced by our company is recombinantly expressed in mammalian cells and has high purity, high immunogenicity and high biological activity. It has high affinity for the therapeutic antibody Erbitux.

​

Expression host: HEK293 mammalian cells

Source: A DNA sequence encoding the extracellular region of human EGFR (NM_005228.3)

Storage buffer: PBS (pH7.4)

Molecular weight: around 95-115kDa (SDS-PAGE detection)

Purity: ≥95% (SDS-PAGE detection)

Storage conditions: short-term storage at 4℃ or long-term storage at -20℃, try to avoid repeated freezing and thawing

Transport conditions: low temperature ice pack

Safety Tips: Not for human experimentation

​