TNFRSF5（CD40）

CD40, also known as TNFRSF5, is a member of the tumor necrosis factor receptor superfamily (TNFR-SF) and is a type I transmembrane glycoprotein with a molecular mass of 45-50kDa. It contains the amino-terminal 173 AA extracellular region, transmembrane region, and 62 AA cytoplasmic region. Like other members of the TNFR family, the extracellular segment of the CD40 molecule has four serine-rich amino acid repeat sequences (CRDs1-CRDs4), and the regions that bind to CD40L are mainly CRD2 and CRD3. CD40 is mainly expressed on B cells, thymic epithelial cells, activated monocytes/macrophages, dendritic cells, hematopoietic cells, epithelial cells, endothelial cells and some tumors (such as ovarian cancer, nasopharyngeal cancer, bladder cancer, liver cancer, Adenocarcinoma, Hodgkin's disease, chronic lymphocytic leukemia, non-Hodgkin B lymphoma, multiple myeloma, non-small cell lung cancer) cells, etc. In the thymus, CD40 is expressed on cortical and medullary epithelial and thymic stromal cells. These cells continue to express CD40 at low levels in non-disease states. When stimulated by inflammatory cytokines such as IL-1, IL-3, TNF-α, GM-CSF, IFN-γ, etc., the ability of these cells to express CD40 is significant. Enhanced, and when stimulated with IFN-γ, CD40 expression is most obviously up-regulated, and can stimulate tumor cells to express CD40.

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The CD40-his and CD40-Fc expressed by mammalian cells of our company have high purity and good activity.

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CD40(His tag) CD40 (Fc tag)

Cat# Abt-P-4008 a Cat#Abt-P-4008 b

Expression host: HEK293 Expression host: HEK293

Molecular weight: 28-34kDa Molecular weight: 55-60kDa

Concentration: 1-2mg/mL Concentration: 1-2mg/mL

Purity: >90% Purity: >90%

Storage environment: 1×PBS (pH7.4) Storage environment: 1×PBS (pH:7.4)

Storage conditions: short-term storage at 4℃, long-term storage at -20℃. Avoid repeated freezing and thawing

Safety Tips: Not for human experimentation

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