β2 Microglobulin Antibody（β2-MG Ab）

β2 microglobulin, also called B2M, is a member of MHC class I molecules. It is present in all nucleated cells, but does not include red blood cells. In humans, β2 microglobulins are encoded by the B2M gene.

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β2 microglobulin not only binds to the α chain of MHCI molecules, but also binds to MHCI-like molecules such as CD1 and Qa. Another additional function of β2 microglobulin is to bind to HFE protein and jointly regulate the expression of hepcidin in the liver. Hepcidin degrades the iron transport membrane protein on the cytoplasmic membrane of intestinal epithelial cells and macrophages, resulting in food The uptake of iron ions is reduced and the iron ions in the red blood cells are released. Loss of this function results in iron excess and hemoglobin deposition. When patients undergo long-term hemodialysis, β2 microglobulin can polymerize into amyloid fibers and deposit in bones and joints. This disease is called dialysis-related amyloidosis.

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β2 microglobulin is necessary for cell surface expression of MHC class I proteins and stability of the peptide binding domain. In fact, in the absence of β2 microglobulin, very few MHC class I proteins (either canonical or atypical) are detected on the cell surface. In the absence of MHC class I proteins, CD8 T cells, a subset of T cells produced during acquired immunity, cannot grow. Low levels of β2 microglobulin reflect the lack of spread of HIV.

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Beta2 microglobulin levels are elevated in patients with multiple myeloma and lymphoma; however, in these cases, primary amyloidosis (amyloid light chain) and secondary amyloidosis (amyloid protein-related proteins) are relatively common. The normal content of β2 microglobulin is less than 2mg/L. However, for multiple myeloma, the expression of β2 microglobulin may also exceed the normal content. When performing diagnostic testing for multiple myeloma, the detection of β2 microglobulin content is an important indicator. If a patient's beta2 microglobulin level is less than 4 mg/L, the median expected survival is 43 months. However, if the beta2 microglobulin level is greater than 4 mg/L, the median survival is only 12 months. moon. However, β2 microglobulin is different from those monoclonal immunoglobulins of uncertain significance (MGUS), which has a better prognostic effect in the observation of myeloma (low grade).

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Our company's β2 microglobulin antibodies have high titers and can be directly used in the development or production of β2 microglobulin detection reagents.

Source: Rabbit, polyclonal antibody

Purification method: Protein A affinity purification

Titer: 1:1 million

Buffer composition: PBS, 0.1% preservative

Storage conditions: It can be stored for one year at 4℃ and two years at -20℃ (it is recommended to store in separate packages and try to avoid repeated freezing and thawing)

Safety Tips: Not for human experimentation