Tetanustoxin C fragment TTc (tet-C)

Tetanus often occurs after trauma. If a body wound is infected by anaerobic Clostridium tetani, the bacteria will grow in a hypoxic environment and produce exotoxins, causing acute and fatal neurological diseases. The clinical manifestations of tetanus are shocking, and it has a high morbidity and mortality rate. Therefore, the disease has attracted great attention and has become a concern of the medical community around the world.

Tetanus toxin (TT) has a full length of 1315 amino acids and a relative molecular mass of approximately 150 kDa. It can be cleaved by papain into light and heavy chains connected by disulfide bonds. According to the role of toxins in the body, they are divided into three parts: A, B, and C. Tetanus toxin C fragment (TTc) is the C-terminus of the heavy chain, with a relative molecular mass of about 50kDa. It is the binding region of the toxin and has good immunogenicity. Its allergenicity is lower than that of tetanus toxoid, and it is promising. Become a new vaccine antigen. In addition, TTc can also be used as a carrier protein for the development of conjugate vaccines, and is also expected to become a carrier for neural-targeted drugs.

The Tetanustoxin C fragment (TTc) provided by our company is recombinantly expressed. High activity and stable

Dosage form: solution or dry powder

Source: Recombinant expression

​Molecular weight: about 45 kDa

Purity: ≥90% (SDS-PAGE detection)

Preservation solution: 0.01M PBS, pH 7.4

Transport conditions: low temperature

Stability and Storage: Solution must be stored within one week at 4°C from date of receipt. Stable for several years at temperatures from -20°C to -80°C. Repeated freeze-thaw cycles should be avoided in the frozen state.

Safety Tip: This reagent is only used for research and development or production, and is strictly prohibited for use in human experiments.