Dickkopf-1（DKK-1）

Dickkopf-related protein 1 is a protein that in humans is encoded by the DKK1 gene.

This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the Wnt signaling pathway. Dickkopf WNT signaling pathway inhibitor 1 (Dkk1) is a protein-coding gene that acts from the anterior visceral endoderm. The dickkopf protein encoded by DKK1 is an antagonistic inhibitor of the WNT signaling pathway that acts by isolating the LRP6 co-receptor so that it cannot aid in activating the WNT signaling pathway. This inhibition plays a key role in head and forelimb development during anterior morphogenesis of the embryo. inhibition of the Wnt signaling pathway by DKK1 is crucial to proper cranial development.

DKK1 is one of the most upregulated genes in androgen-potentiated balding, with DKK-1 messenger RNA upregulated a few hours after DHT treatment of hair follicles at the dermal papilla in vitro. Neutralizing body against DKK-1 reversed DHT effects on outer root sheath keratinocytes. DKK-1 expression is attenuated by L-threonate in vitro, with the latter a metabolite of ascorbate.

Elevated levels of DKK1 in bone marrow, plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma. Currently the DKK1 is regarded as the cancer biomarker ,especially for liver cancer early diagnosis . In addition , DKK1 obviously represses the growth and maturity of cervical carcinoma Hela cell .

The DKK1 provided by our company is gene recombinant protein of mammalian cell, with a high purity, good immunogenicity and high biological activity. Antibody to this antigen protein can be used as the core material of liver cancer early diagnosis kit and the protein itself can also be used as calibration items.

Product description:

Appearance: Colorless liquid (White powder, lyophilized for special demand)

Protein concentration: 1 mg/ml

Basic information:

Cat#: Abt-P-2010                          

Source: Recombination expression in mammalian cells

MW: About 44 kDa (SDS-PAGE)           

Purity: 95% or more (SDS-PAGE)

Storage：4 °C for frequent usage，-20℃ for much longer，Avoid freeze / thaw cycle.

Transportation: Cold packs        

Safety tips: Do not use for human experiments