Retinol Binding Protein 4（RBP4）

Retinol binding protein 4 (RBP4) is a newly discovered adipokine that is expressed and secreted in adipose tissue and is involved in the occurrence of insulin resistance. RBP4 is not a newly discovered protein, it belongs to the retinol-binding protein (RBP) family. Retinol-binding protein is a type of specific transport protein in the body that transports vitamin A and its various active metabolites from the liver to target tissues, assisting vitamin A in exerting its physiological functions. Retinol-binding proteins can be divided into five categories based on sequence homology: serum retinol-binding protein (RBP), intracellular retinol-binding protein (CRBP), intracellular retinoic acid-binding protein (CRABP), and intracellular retinol-binding protein (CRABP). Internal retinaldehyde binding protein (CRALBP) and photoreceptor retinoid binding protein (IRBP). The latter four are all intracellular binding proteins, and RBP4 is the serum retinol-binding protein. It is the main extracellular transport protein and is responsible for binding and transporting retinol in the blood.

RBP4 is a single peptide chain protein with a molecular weight of approximately 21kDa, composed of 181 amino acids, and has a site-specific binding to a molecule of all-trans retinol. Multiple studies in different populations have shown that RBP4 levels are positively correlated with triglycerides (TG) and negatively correlated with high-density lipoprotein cholesterol (HDL-C), which may be related to the synthesis of TG in the liver and the release of VLDL into the blood to increase insulin resistance. Status related. In addition, RBP4 affects the metabolism of fatty acids. Dysregulation of fatty acid metabolism is closely related to insulin resistance. RBP4 affects the action of insulin by regulating lipid metabolism.

In addition, studies have shown a strong correlation between RBP4 levels and reduced flow-regulated vasodilation, increased urinary albumin excretion rate, and retinopathy, suggesting that serum RBP4 levels may serve as a reference for vascular complications in type 2 diabetes. index.

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Protein accession: NP_006735.2

Expression host: HEK293

Purity: ≥ 90% (SDS-PAGE)

Molecular weight: about 22kDa

Storage buffer: 1×PBS (pH7.4)

Storage: Store at 4°C for frequent use and long-term storage at -20°C. Avoid repeated freezing and thawing.