Cystatin C（Cys C）

Cystatin C or cystatin 3 (formerly gamma trace, post-gamma-globulin or neuroendocrine basic polypeptide), a protein encoded by the CST3 gene, is mainly used as a biomarker of kidney function. Recently, it has been studied for its role in predicting new-onset or deteriorating cardiovascular disease. It also seems to play a role in brain disorders involving amyloid (a specific type of protein deposition), such as Alzheimer's disease. In humans, all cells with a nucleus (cell core containing the DNA) produce cystatin C as a chain of 120 amino acids. It is found in virtually all tissues and body fluids. It is a potent inhibitor of lysosomal proteinases (enzymes from a special subunit of the cell that break down proteins) and probably one of the most important extracellular inhibitors of cysteine proteases (it prevents the breakdown of proteins outside the cell by a specific type of protein degrading enzymes). Cystatin C belongs to the type 2 cystatin gene family.

Cys C  is removed from the bloodstream by glomerular filtration in the kidneys，and be reabsorbed by proximal tubule, then metabolic breakdown , therefore its concentration in the blood is determined by glomerular filtration without relying on any external factors, such as age, sex, race and eating habits, that can be used as a ideal homology marker of the glomerular filtration rate.

Normally, the concentration of Cys C in serum and plasma is between 0.51-1.09 mg/L (reference range). When kidney function is impaired, the concentration of Cys C changes in the blood with the glomerular filtration rate Cys C concentration in the blood increased by 10 times following glomerular filtration rate drops when renal failure. If glomerular filtration rate is normal but renal tubular dysfunction will hinder the absorption decomposition of Cys C in the renal tubules, leading to the concentration of the urine increased by 100 times.

The Cys C provided by our company is the recombinant human protein，with high immunogenicity. it is not only used to immune animal for producing anti-Cys C antibody, which can be used as the core material for the Cys C diagonosis kit, but also can be used as a quality control standard or positive control test.

Product description:

Appearance: White powder, lyophilized or colorless liquid

Preservation solution: PBS, pH7.4

Basic information:

Cat#: Abt-P-2003                          

Source: Recombinant expression

Molecular weight: About 13kDa (SDS-PAGE detection)

Purity: ≥90% (SDS-PAGE test)

Storage: 4℃, store at -20℃ for long-term preservation

Transportation: Cold packs       

Safety tips: Do not use for human experiments