Cystathionine gamma-lyase（CGL）

Cystathionine gamma-lyase (CGL), or cystathionase ( CSE),  EC 4.4.1.1) , the enzyme participating in the synthesis of cysteine, catalyzes cystathionine deamination action, and form cysteine, alpha ketone butyric acid and NH3.

Cystathionine gamma-lyase also catalyzes the following elimination reactions:

· L-homoserine to form H2O, NH3 and 2-oxobutanoate

· L-cystine, producing thiocysteine, pyruvate and NH3

· L-cysteine  producing pyruvate, NH3 and H2S

In some bacteria and mammals, including humans, this enzyme takes part in generating hydrogen sulfide. Hydrogen sulfide is one of a few gases that was recently discovered to have a role in cell signaling in the body.

As a new gaseous signal molecular, H2S has the similar but different mechanisms with carbon monoxide(CO), nitric oxide(NO) in diastolic function for blood vessels, which has several function such as the proliferation of vascular smooth muscle, the dilation of coronary artery, increasing myocardial blood flow, reducing myocardial oxygen consumption and myocardial protection. CGL is an important endogenous enzyme, which produce H2S in cardiovascular and primarily existed in the vascular smooth muscle, endothelial cells.

H2S plays an important role in the regulation of the body's microcirculation, especially the regulation of physiological/pathological processes and related syndromes in the cardiovascular system. Because of the close relationship between CGL and H2S, the study on CGL is of great significance.

Product description:

Appearance: Yellowish liquid (or lyophilized powder)

Preservation solution: Phosphate buffer, pH7.4

pH stability: 7.0 - 9.0

Basic information:

Cat#: Abt-P-1010                           

Source: Recombinant expression

Molecular weight: About 44kDa (SDS-PAGE detection)

Purity: ≥90% (SDS-PAGE test)

Storage: 4℃, store at -20℃ for long-term preservation, avoid freeze/thaw cycle

Transportation: Cold packs       

Safety tips: Do not use for human experiments