GITR(glucocorticoid—induced tumor necrosis factor receptor)

GITR (glucocorticoid-induced tumor necrosis factor receptor), also known as AITR or TNFRSF18, is a glucocorticoid-induced tumor necrosis factor receptor protein. It is a new member of the TNFR superfamily and plays a role in immune regulation.

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So far, there have been many studies on the role of GITR signaling in the acquired immune system, but limited research on innate immunity. Innate immunity is an important part of body immunity. Mononuclear macrophages process antigens, activate lymphocytes, and phagocytose. Bacteria and other aspects have important functions. When effector T cells are activated, there is a temporary upregulation of GITR. When GITR signaling is triggered, the inhibitory effect mediated by TGFβ-1 can be abolished.

Human GITR(Histag) Human GITR(Fc tag)

Cat# Abt-P-4013 a Cat# Abt-P-4013 b

Expression host: HEK293 Expression host: HEK293

Molecular weight: 25 kDa Molecular weight: 45-52 kDa

Concentration: 1-2mg/mL Concentration: 1-2mg/mL

Purity: >90% Purity: >90%

Storage environment: 1×PBS (pH7.4) Storage environment: 1×PBS (pH7.4)

Storage conditions: short-term storage at 4℃, long-term storage at -20℃. Avoid repeated freezing and thawing

Safety Tips: Not for human experimentation