Cluster of Differentiation 28（CD28）

T cell surface molecule CD28 (Cluster of Differentiation 28) is a costimulatory signal molecule expressed by T cells. This costimulatory signal is necessary for T cell activation. As a member of the immunoglobulin superfamily of adhesion molecules, the ligands of CD28 are B7-1 (CD80) and B7-2 (CD86). The highly conserved MYPPPY motif in the V-like region of the CD28 molecule binds to the B7 molecule. parts.

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CD28 can exert a co-stimulatory effect when combined with its natural ligand B7. It acts as a second signal to activate T cells, promotes T cell proliferation and secretes a variety of cytokines, and induces T and B cell adhesion to prevent the formation of clonal unresponsiveness.

Human CD28(Fc tag)

Cat#Abt-P-4006

Expression host: HEK293

​Molecular weight: 55-72 kDa

Concentration: 1-2mg/mL

Purity: >90%

Storage environment: 1×PBS (pH7.4)

Storage conditions: short-term storage at 4℃, long-term storage at -20℃. Avoid repeated freezing and thawing

Safety Tips: Not for human experimentation